ネットワークモデル

積分発火モデル　ミツバチにおいては，カルシウムイメージング実験により，触角葉への入力パターンおよび出力パターンが明らかにされている．Galiziaらは，積分発火モデルを用いた計算機実験により，局所介在神経による糸球体同士の接続パターンを検証した．その結果，ランダムな接続・距離に依存した接続に対し，入力情報がよく似た糸球体同士を選択的に局所介在神経で接続した場合に，出力パターンをよく再現できることを示した[Linster et al., 2005]．のちに，距離に依存しない相互作用は，様々な昆虫で発見された[Reisenman et al., 2008; Olsen et al., 2007; Namiki & Kanzaki, 2008]．
Hodgkin-Huxleyタイプモデル　バッタの嗅覚系では，イオン電流を考慮したタイプのネットワークモデルが作られている[Bazhenov et al., 2001a, b]．各ニューロンは，単一コンパートメントで構成され，スパイクタイミング依存型の可塑性を考慮し，同期的振動現象や，匂いの短期記憶の再現をしている[Bazhenov et al., 2005]．

神経形態を考慮に入れたモデル

局所介在神経の相互作用に関しては，以前から細胞内計測を行って，複数の異なる振幅のスパイクが観察されていたことから[Matsumoto & Hildebrand, 1981; Christensen et al., 1993]，複数の活動電位の発生部位があり，また局所的な情報処理を行うのではないかと考えられていた．この可能性を検証するための，マルチコンパートメントモデルによるシミュレーションが行われている[Christensen et al., 2001]．カイコガでも同様の計算機実験により，例えば，局所的なシナプス入力に対しては局所的な作用，複数部位への同時シナプス入力に対しては，全体に拡散する作用を示す現象が観察されている．モデルの精緻化のため，イメージング等による単一細胞活動の多点同時計測等の実験データの取得が待たれる．
[状況によって，昆虫に限らず工学分野で提案されている識別システムについて，短く追加するかもしれません．]

Aungst, J. L., Heyward, P. M., Puche, A. C., Karnup, S. V., Hayar, A., Szabo, G. & Shipley, M. T. (2003) Centre-surround inhibition among olfactory bulb glomeruli. Nature, 426, 623-629.

Bazhenov M, Stopfer M, Rabinovich M, Abarbanel HD, Sejnowski TJ, Laurent G (2001) Model of cellular and network mechanisms for odor-evoked temporal patterning in the locust antennal lobe. Neuron 30:569-581.

Bazhenov M, Stopfer M, Rabinovich M, Huerta R, Abarbanel HD, Sejnowski TJ, Laurent G (2001) Model of transient oscillatory synchronization in the locust antennal lobe. Neuron 30:553-567.]

Bazhenov M, Stopfer M, Sejnowski TJ, Laurent G (2005) Fast odor learning improves reliability of odor response in the locust antennal lobe. Neuron 46:483-492.

Bhandawat V, Olsen SR, Gouwens NW, Schlief ML, Wilson RI (2007) Sensory processing in the Drosophila antennal lobe increases reliability and separability of ensemble odor representations. Nat Neurosci 10:1474-1482.

Christensen TA, D’Alessandro G, Lega J, Hildebrand JG (2001) Morphometric modeling of olfactory circuits in the insect antennal lobe: I. Simulations of sipiking local interneurons. Biosystems 61:143-153.

Christensen TA, Lei H, Hildebrand JG (2003) Coordination of central odor representations through transient, non-oscillatory synchronization of glomerular output neurons. Proc Natl Acad Sci USA 19:11076-11081.

Christensen TA, Waldrop BR, Harrow ID, Hildebrand JG (1993) Local interneurons and information processing in the olfactory glomeruli of the moth Manduca sexta. J Comp Physiol A 173:385-399.

Friedrich RW (2006) Mechanisms of odor discrimination: neurophysiological and behavioral approaches. Trends Neurosci 29, 40-47.

Friedrich RW, Habermann CJ, Laurent G (2004) Multiplexing using synchrony in the zebrafish olfactory bulb. Nat Neurosci 7:862-871.

Friedrich RW, Laurent G (2001) Dynamic optimization of odor representation by slow temporal patterning of mitral cell activity.　Science, 291, 889-894.

Hayar, A., Karnup, S., Ennis, M. & Shipley, M. (2004) External tufted cells: a major excitatory element that coordinates glomerular activity. J. Neurosci., 24, 6676-6685.

Ito, I., Ong, R. C., Raman, B. & Stopfer, M. (2008) Sparse odor representation and olfactory learning. Nat. Neurosci. 11, 1177-1184.

Kazawa, T., Namiki, S., Fukushima, R., Terada, M., Soo, K. & Kanzaki, R. (2009) Constancy and variability of glomerular organization in the antennal lobe of the silkmoth. Cell Tissue Res., 336, 119-136.

Krofczik, S., Menzel, R. & Nawrot, M. P. (2008) Rapid odor processing in the honeybee antennal lobe network. Front. Comput. Neurosci., 2, 9.

Laurent, G. (2002) Olfactory network dynamics and the coding of multidimensional signals. Nat. Rev. Neurosci. 3, 884-895.
Linster C, Sachse S, Galizia CG (2005) Computational modeling suggests that response properties rather than spatial position determine connectivity between olfactory glomerul. J Neurophysiol 93:3410-3417.

Matsumoto SG, Hildebrand JG (1981) Olfactory mechanisms in the moth Manduca sexta: response characteristics and morphology of central neurons in the antennal lobes. Proc R Soc Lond B 213:249-277.
Mombaerts, P., Wang, F., Dulac, C., Chao, S. K., Nemes, A., Mendelsohn, M., Edmondson, J. & Axel, R. (1996) Visualizing an olfactory sensory map. Cell, 87, 675-686.

Namiki, S. & Kanzaki, R. (2008) Reconstructing the population activity of olfactory output neurons that innervate identifiable processing units. Front. Neurosci., 2, 1.

Olshausen B, Field D (2004) Sparse coding of sensory inputs. Curr Opin Neurobiol 14:481-487.

Olsen, S. R., Bhandawat, V. & Wilson, R. I. (2007) Excitatory interactions between olfactory processing channels in the Drosophila antennal lobe. Neuron, 54, 89-103.

Perez-Orive, J., Mazor, O., Turner, G. C., Cassenaer, S., Wilson, R. I. & Laurent, G. (2002) Oscillation and sparsening of odor representations in the mushroom body. Science, 297, 359-365.

Reisenman CE, Heinbockel T, Hildebrand JG (2008) Inhibitory interactions among olfactory glomeruli do not necessarily reflect spatial proximity. J Neurophysiol 100:554-564.

Shang, Y., Claridge-Chang, A., Sjulson, L., Pypaert, M. & Miesenböck, G. (2007) Excitatory local circuits and their implications for olfactory processing in the fly antennal lobe. Cell, 128, 601-612.

Staudacher, E. M., Huetteroth, W., Schachtner, J. & Daly, K. C. (2009) A 4-dimensional representation of antennal lobe output based on an ensemble of characterized projection neurons. J. Neurosci. Methods, 180, 208-223.
T
anaka, N. K., Ito, K. & Stopfer, M. (2009) Odor-evoked neural oscillations in Drosophila are mediated by widely branching interneurons. J. Neurosci., 29, 8595-8603.

Uchida N, Mainen ZF (2003) Speed and accuracy off olfactory discrimination in the rat. Nat Neurosci 6:1224-1229.

Vosshall, L. B., Wong, A. M. & Axel, R. (2000) An olfactory sensory map in the fly brain. Cell, 102, 147-159.

Wilson, R. I., Turner, G. C. & Laurent, G. (2004) Transformation of olfactory representations in the Drosophila antennal lobe. Science 303, 366-370.

Yokoi M, Mori K, Nakanishi S (1995) Refinement of odor molecule tuning by dendrodendritic synaptic inhibition in the olfactory bulb. Proc Natl Acad Sci USA 92:3371-3375.